This perspective article examines the role that partnerships can play in achieving the Sustainable Development Goals (SDGs). It elucidates a portfolio approach to partnerships that could align well with achieving a sustainable transformation. To conclude, it outlines recommendations on how this approach may be operationalized in research, policy, and practice. Much remains to be done on a portfolio approach. Practice and sharing of good practice should be guiding principles to facilitate peer-to-peer learning. It is also important to address power imbalances, conflicting interests, and limited representation in partnerships.